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      Recombinant Mouse Flt-3 Ligand/FLT3L Protein
       
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      產(chǎn)品說明書
                  
      FAQ
                  
      COA
                  
      已發(fā)表文獻(xiàn)
                  
       
      產(chǎn)品簡介
      


      Flt3配體是一種調(diào)節(jié)早期造血細(xì)胞增殖的生長因子,其與表達(dá)酪氨酸激酶受體Flt3的細(xì)胞結(jié)合。Flt3配體本身不刺激早期造血細(xì)胞的增殖，但與其他CSF和白細(xì)胞介素協(xié)同誘導(dǎo)生長和分化。與SCF不同，F(xiàn)lt3配體對肥大細(xì)胞不發(fā)揮活性。Flt3配體的多種異構(gòu)體已被鑒定，主要的生物活性形式作為跨膜蛋白的細(xì)胞外結(jié)構(gòu)域錨定在細(xì)胞表面（209 a.a.）。膜結(jié)合的同種型可以被蛋白水解裂解以產(chǎn)生具有生物活性的可溶性同種型。
      


      本品重組小鼠Flt3配體以液體形式提供，高活性、高純度、低內(nèi)毒素、無標(biāo)簽。
      


       
      


      性能參數(shù)
      


      
	
		
      
			
			
      Synonyms
      
			      		
			
			
      FL; FLG3L; Flt3 ligand; Flt-3 Ligand; Flt3L; FLT3LG; fms-related tyrosine kinase 3 ligand
      
			      		
		
      
		
      
			
			
      Uniprot No.
      
			      		
			
			
      P49772
      
			      		
		
      
		
      
			
			
      Source
      
			      		
			
			
      Mouse FLt3L Protein is expressed from HEK293 without tag. It contains Gly27-Arg188.
      
			      		
		
      
		
      
			
			
      Molecular Weight
      
			      		
			
			
      The protein has a predicted 18.4 kDa
      
			      		
		
      
		
      
			
			
      Purity
      
			      		
			
			
      > 95% as determined by SDS-PAGE.
      
			      		
		
      
		
      
			
			
      Biological Activity
      
			      		
			
			
      Measured in a cell proliferation assay using BaF3 mouse pro-B cells transfected with mouse Flt-3. The EC50 for this effect is 0.04-2.4 ng/mL.
      
			      		
		
      
		
      
			
			
      Endotoxin
      
			      		
			
			
      < 0.01 EU per 1μg of the protein by the LAL method.
      
			      		
		
      
		
      
			
			
      Formulation
      
			      		
			
			
      Dissolved in sterile PBS buffer.
      

			
      This solution can be diluted into other aqueous buffers. Centrifuge the vial prior to opening.
      
			      		
		
      
		
      
			
			
      Concentration
      
			      		
			
			
      0.2 mg/mL
      
			      		
		
      
	      

      


       
      


      儲存條件
      


      The product should be stored at -85~-65℃ for 1 year from date of receipt.
      


      Recommend to aliquot the protein into smaller quantities when first used and avoid repeated freeze-thaw cycles.
      


       
      


      注意事項(xiàng)
      


        
	
      1. Please operate with lab coats and disposable gloves,for your safety.   
        2. 
	
      2. This product is for research use only. 
        3. 

      


      Ver. CN20240202
      


       
      

         
       
       
       
       
       
       
       
      400-6111-883