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      Recombinant Human Proinsulin C-Peptide Analogue
       
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      產品說明書
                  
      FAQ
                  
      COA
                  
      已發(fā)表文獻
                  
       
      This gene encodes insulin, a peptide hormone that plays a vital role in the regulation of carbohydrate and lipid metabolism. After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants.
      


       
      


      Product Properties
      


      
	
		
      
			
			
      Synonyms
      
			      		
			
			
      Human Proinsulin C-Peptide Analogue, IDDM Protein, Human; IDDM1 Protein, Human
      
			      		
		
      
		
      
			
			
      Accession
      
			      		
			
			
      P01308
      
			      		
		
      
		
      
			
			
      GeneID
      
			      		
			
			
      3630
      
			      		
		
      
		
      
			
			
      Source
      
			      		
			
			
      E.coli-derived human Proinsulin C-Peptide Analogue protein,Arg55-Arg89
      
			      		
		
      
		
      
			
			
      Molecular Weight
      
			      		
			
			
      Approximately 3.6 kDa.
      
			      		
		
      
		
      
			
			
      AA Sequence
      
			      		
			
			
      RREAEDLQVG QVELGGGPGA GSLQPLALEG SLQKR
      
			      		
		
      
		
      
			
			
      Tag
      
			      		
			
			
      None
      
			      		
		
      
		
      
			
			
      Physical Appearance
      
			      		
			
			
      Sterile Filtered White lyophilized (freeze-dried) powder.
      
			      		
		
      
		
      
			
			
      Purity
      
			      		
			
			
      > 95 % by SDS-PAGE and HPLC analyses.
      
			      		
		
      
		
      
			
			
      Biological Activity
      
			      		
			
			
      Data Not Available. 
      
			      		
		
      
		
      
			
			
      Endotoxin
      
			      		
			
			
      < 0.1 EU per 1μg of the protein by the LAL method.
      
			      		
		
      
		
      
			
			
      Formulation
      
			      		
			
			
      Lyophilized from a 0.2 µm filtered solution in PBS, pH 7.4.
      
			      		
		
      
		
      
			
			
      Reconstitution
      
			      		
			
			
      We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20°C. Further dilutions should be made in appropriate buffered solutions.
      
			      		
		
      
	      

      


       
      


      Shipping and Storage
      


      The products are shipped with ice pack and can be stored at -20℃ to -80℃ for 1 year.
      


      Recommend to aliquot the protein into smaller quantities when first used and avoid repeated freeze-thaw cycles.
      


       
      


      Cautions
      


      1. Avoid repeated freeze-thaw cycles.
      


      2. For your safety and health, please wear lab coats and disposable gloves for operation.
      


      3. For research use only!
      


       
      


      HB220210
      

         
       
       
       
       
       
       
       
      400-6111-883