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      Mouse aFGF
       
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      產(chǎn)品說(shuō)明書(shū)
                  
      FAQ
                  
      COA
                  
      已發(fā)表文獻(xiàn)
                  
       
      Murine aFGF, encoded by the FGF1 gene, is a member of the fibroblast growth factor (FGF) family. Fibroblast growth factor was found in pituitary extracts in 1973 and then tested in a bioassay that caused fibroblasts to proliferate. After further fractionating the extract using acidic and basic pH, two different forms have isolated that named "acidic fibroblast growth factor" (FGF-1) and "basic fibroblast growth factor" (FGF-2). Murine aFGF shares 52 % amino acid sequence identity with bFGF. Murine aFGF shares 96 % amino acid sequence identity with human aFGF, so it exhibits considerable species crossreactivity between murine and human aFGF. In mammalian FGF receptor family has 4 members, FGFR1, FGFR2, FGFR3, and FGFR4, and 1, 2, 3 have 2 sub-types “b”, “c”. aFGF can bind and activate all 7 different FGFRs. Affinity between aFGF and its receptors can be increased by heparin or heparan sulfate proteoglycan. aFGF plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. 
      


       
      


      Product Properties
      


      
	
		
      
			
			
      Synonyms
      
			      		
			
			
      Fibroblast growth factor 1；FGF-1；Acidic fibroblast growth factor；HBGF-1
      
			      		
		
      
		
      
			
			
      Accession
      
			      		
			
			
      P61148
      
			      		
		
      
		
      
			
			
      GeneID
      
			      		
			
			
      14164
      
			      		
		
      
		
      
			
			
      Source
      
			      		
			
			
      E.coli-derived mouse Acidic Fibroblast Growth Factor protein, Phe16-Asp155
      
			      		
		
      
		
      
			
			
      Molecular Weight
      
			      		
			
			
      Approximately 15.8 kDa.
      
			      		
		
      
		
      
			
			
      AA Sequence
      
			      		
			
			
      FNLPLGNYKK PKLLYCSNGG HFLRILPDGT VDGTRDRSDQ HIQLQLSAES AGEVYIKGTE TGQYLAMDTE GLLYGSQTPN EECLFLERLE ENHYNTYTSK KHAEKNWFVG LKKNGSCKRG PRTHYGQKAI LFLPLPVSSD
      
			      		
		
      
		
      
			
			
      Tag
      
			      		
			
			
      None
      
			      		
		
      
		
      
			
			
      Physical Appearance
      
			      		
			
			
      Sterile Filtered White lyophilized (freeze-dried) powder.
      
			      		
		
      
		
      
			
			
      Purity
      
			      		
			
			
      > 96 % by SDS-PAGE and HPLC analyses.
      
			      		
		
      
		
      
			
			
      Biological Activity
      
			      		
			
			
      Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine balb/c 3T3 cells is less than 0.2 ng/ml, corresponding to a specific activity of > 5.0 × 106 IU/mg in the presence of 10 μg/ml of heparin.
      
			      		
		
      
		
      
			
			
      Endotoxin
      
			      		
			
			
      < 1.0 EU per 1μg of the protein by the LAL method.
      
			      		
		
      
		
      
			
			
      Formulation
      
			      		
			
			
      Lyophilized from a 0.2 µm filtered concentrated solution in PBS, pH 7.4.
      
			      		
		
      
		
      
			
			
      Reconstitution
      
			      		
			
			
      We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
      
			      		
		
      
	      

      


       
      


      Shipping and Storage
      


      The products are shipped with ice pack and can be stored at -20℃ to -80℃ for 1 year.
      


      Recommend to aliquot the protein into smaller quantities when first used and avoid repeated freeze-thaw cycles.
      


       
      


      Cautions
      


      1. Avoid repeated freeze-thaw cycles.
      


      2. For your safety and health, please wear lab coats and disposable gloves for operation.
      


      3. For research use only!
      


       
      


      HB220517
      

         
       
       
       
       
       
       
       
      400-6111-883