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      Recombinant Human PD-L1/B7-H1(His Tag)
       
      更多活動(dòng)更多優(yōu)惠，盡在翌圣商城》
       
       
       
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      產(chǎn)品說(shuō)明書(shū)
                  
      FAQ
                  
      COA
                  
      已發(fā)表文獻(xiàn)
                  
       
      PD-L1, also known as B7-H1, PDL1, is one of the ligands for PD-1 and plays a critical role in the regulation of T cell immunity. The PD-L1 protein is an approximately 65 kDa transmembrane glycoprotein belonging to the B7 family of immune regulatory molecules. Mature human PD-L1 protein consists of a 220 amino acid (aa) extracellular domain (ECD) with two immunoglobulin-like domains, a 21 aa transmembrane segment, and a 31 aa cytoplasmic domain. Within the ECD, human PD-L1 shares 73% and 74% aa sequence identity with mouse and rat B7-H1, respectively. PD-L1 provides a molecular stop signal to the adaptive immune system helping to distinguish between self and foreign antigens. PD-L1 also plays a role in the development of immune tolerance by promoting T cell anergy and enhancing regulatory T cell development.
      


       
      


      產(chǎn)品性質(zhì)
      


      
	
		
      
			
			
      別名（Synonyms）
      
			      		
			
			
      CD274, PDL1, PD-L1B7 homolog 1, B7-H, B7H1, B7-H1, PDCD1L1, PDCD1LG1
      
			      		
		
      
		
      
			
			
      Uniprot No.
      
			      		
			
			
      Q9NZQ7-1
      
			      		
		
      
		
      
			
			
      表達(dá)區(qū)間及表達(dá)系統(tǒng)（Source）
      
			      		
			
			
      HEK293 Cells-derived Human PD-L1 / B7-H1 Protein, Phe19-Arg238 with His tag at the C-terminal
      
			      		
		
      
		
      
			
			
      分子量(Molecular Weight)
      
			      		
			
			
      Approximately 26.0 kDa. Due to glycosylation, the protein migrates to 35-42 kDa based on Tris-Bis PAGE result.
      
			      		
		
      
		
      
			
			
      外觀(Physical Appearance）
      
			      		
			
			
      Sterile Filtered White lyophilized (freeze-dried) powder.
      
			      		
		
      
		
      
			
			
      純度（Purity）
      
			      		
			
			
      > 95% as determined by SDS-PAGE and HPLC
      
			      		
		
      
		
      
			
			
      活性（Activity）
      
			      		
			
			
      ELISA Data: Immobilized Human PD-L1, His Tag at 0.5 μg/mL (100 μL/Well). Dose response curve for Anti-PD-L1 Ab., hFc Tag with the EC50 of 6.1 ng/mL determined by ELISA.
      
			      		
		
      
		
      
			
			
      內(nèi)毒素（Endotoxin）
      
			      		
			
			
      < 1.0 EU per 1μg of the protein by the LAL method.
      
			      		
		
      
		
      
			
			
      制劑（Formulation）
      
			      		
			
			
      Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 5% trehalose is added as protectant before lyophilization.
      
			      		
		
      
		
      
			
			
      復(fù)溶（Reconstitution）
      
			      		
			
			
      Centrifuge tubes before opening. Reconstituting to a concentration more than 100 μg/mL` is recommended (usually we use 1mg/mL solution for lyophilization). Dissolve the lyophilized protein in distilled water.
      
			      		
		
      
	      

      


       
      


      運(yùn)輸與保存方法
      


      冰袋運(yùn)輸。-20℃至-80℃保存，一年有效期。
      


      復(fù)溶后，-20 至 -80°C，在未開(kāi)封狀態(tài)下保存 3-6 個(gè)月。復(fù)溶后，2-8°C 保存 2-7 天。
      


      建議第一次使用時(shí)分裝凍存，避免反復(fù)凍融。
      


       
      


       注意事項(xiàng)
      


      1. 避免反復(fù)凍融。
      


      2. 為了您的安全和健康，請(qǐng)穿實(shí)驗(yàn)服并戴一次性手套操作。
      


      3. 本產(chǎn)品僅作科研用途！
      


       
      


      產(chǎn)品數(shù)據(jù)
      
image.png
      


      HB220629
      


       
      

         
       
       
       
       
       
       
       
      400-6111-883