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      Recombinant Human EGFR/HER1 Protein, hFc Tag
       
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      產(chǎn)品說明書
                  
      FAQ
                  
      COA
                  
      已發(fā)表文獻(xiàn)
                  
       
       
      


      The EGFR subfamily of receptor tyrosine kinases comprises four members: EGFR , ErbB2, ErbB3, and ErbB4. All family members are type I transmembrane glycoproteins. EGFR binds a subset of the EGF family ligands, including EGF, amphiregulin, TGF-alpha, betacellulin, epiregulin, and HB-EGF. Ligand binding induces EGFR homodimerization as well as heterodimerization with ErbB2, resulting in kinase activation, heterodimerization tyrosine phosphorylation and cell signaling. EGFR signaling regulates multiple biological functions including cell proliferation, differentiation, motility, and apoptosis. EGFR is overexpressed in a wide variety of tumors and is the target of several anti-cancer drugs.  
      


       
      


      產(chǎn)品性質(zhì)
      


      
	
		
      
			
			
      別名
      
			      		
			
			
      ErbB; EC 2.7.10; EC 2.7.10.1; EGFR; mENA; LEGFR; ERBB; ERBB1; HER1; PIG61; NISBD2
      
			      		
		
      
		
      
			
			
      Uniprot No.
      
			      		
			
			
      P00533
      
			      		
		
      
		
      
			
			
      表達(dá)區(qū)間及表達(dá)系統(tǒng)
      
			      		
			
			
      Recombinant Human EGFR/HER1 Protein is expressed from HEK293 Cells with hFc tag at the C-terminal. It contains Leu25-Ser645.
      
			      		
		
      
		
      
			
			
      分子量
      
			      		
			
			
      Approximately 95.2 kDa. Due to glycosylation, the protein migrates to 140-160 kDa based on Tris-Bis PAGE result.
      
			      		
		
      
		
      
			
			
      純度
      
			      		
			
			
      > 95% as determined by SDS-PAGE and HPLC.
      
			      		
		
      
		
      
			
			
      活性
      
			      		
			
			
      ELISA Data：Immobilized Human EGF at 2μg/ml (100μl/well) on the plate. Dose response curve for Human EGFR, hFc Tag with the EC50 of 81.0ng/ml determined by ELISA.
      
			      		
		
      
		
      
			
			
      內(nèi)毒素
      
			      		
			
			
      < 1.0 EU per 1μg of the protein by the LAL method.
      
			      		
		
      
		
      
			
			
      制劑
      
			      		
			
			
      Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 5% trehalose is added as protectant before lyophilization.
      
			      		
		
      
		
      
			
			
      復(fù)溶
      
			      		
			
			
      Centrifuge tubes before opening. Reconstituting to a concentration more than 100 μg/mL is recommended (usually we use 1 mg/mL solution for lyophilization). Dissolve the lyophilized protein in distilled water.
      
			      		
		
      
	      

      


       
      


      運(yùn)輸與保存方法
      


      The products are shipped with ice pack and can be stored at -20℃ for 1 year.
      


      2-7 days, 2 to 8 °C under sterile conditions after reconstitution.
      
3 months, -20 °C under sterile conditions after reconstitution.
      


      Recommend to aliquot the protein into smaller quantities for optimal storage. Please avoid freeze-thaw cycles.
      


       
      


      注意事項
      


      1.For your safety and health, please wear lab coats and disposable gloves for operation. 
      


      2.For research use only!
      


       
      


      產(chǎn)品數(shù)據(jù)
      


      


      


      HB221118
      

         
       
       
       
       
       
       
       
      400-6111-883