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      Biotinylated Human IL-1R3/IL-1 RAcP Protein, His-Avi Tag
       
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      產(chǎn)品說明書
                  
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      IL-1R3, also known as IL-1 Receptor Accessory Protein (IL-1 RAcP), is a ubiquitously expressed 70-90 kDa member of the Interleukin-1 receptor family of proteins. It serves as a non-ligand-binding component of the receptors for IL-1 alpha, IL-1 beta, IL-33, and IL-36. Within the ECD, human IL-1 RAcP shares 86% aa sequence identity with mouse and rat IL-1 RAcP. It is a subunit of the functional signaling complex with IL-1 RI and associates with IL-1 RII in a non-signaling receptor complex. In addition, it interacts with ST2/IL-1 R4 on mast cells and Th2 cells to create a functional IL-33 receptor complex.
      


       
      


      產(chǎn)品性質(zhì)
      


      
	
		
      
			
			
      Synonyms
      
			      		
			
			
      IL1RAP; IL-1RAP; C3orf13; IL-1 R3; IL-1 RAcP
      
			      		
		
      
		
      
			
			
      Uniprot No.
      
			      		
			
			
      Q9NPH3-1
      
			      		
		
      
		
      
			
			
      Source
      
			      		
			
			
      Recombinant Biotinylated Human IL-1R3/IL-1 RAcP Protein is expressed from HEK293 Cells with His tag and Avi tag at the C-terminal. It contains Ser21-Glu359.
      
			      		
		
      
		
      
			
			
      Molecular Weight
      
			      		
			
			
      The protein has a predicted MW of 42 kDa. Due to glycosylation, the protein migrates to 52-70 kDa based on Tris-Bis PAGE result.
      
			      		
		
      
		
      
			
			
      Physical Appearance
      
			      		
			
			
      Sterile Filtered White lyophilized (freeze-dried) powder.
      
			      		
		
      
		
      
			
			
      Purity
      
			      		
			
			
      > 95% as determined by SDS-PAGE and HPLC
      
			      		
		
      
		
      
			
			
      Endotoxin
      
			      		
			
			
      < 1.0 EU per 1μg of the protein by the LAL method.
      
			      		
		
      
		
      
			
			
      Formulation
      
			      		
			
			
      Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 5% trehalose is added as protectant before lyophilization.
      
			      		
		
      
		
      
			
			
      Reconstitution
      
			      		
			
			
      Centrifuge tubes before opening. Reconstituting to a concentration more than 100μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
      
			      		
		
      
	      

      


       
      


      運(yùn)輸與保存方法
      


      The products are shipped with ice pack and can be stored at -20℃ for 1 year.
      


      2-7 days, 2 to 8 °C under sterile conditions after reconstitution.
      
3 -6 months, -20 to -80°C under sterile conditions after reconstitution.
      


      Recommend to aliquot the protein into smaller quantities for optimal storage. Please avoid freeze-thaw cycles.
      


       
      


      注意事項(xiàng)
      


        
	
      1. For your safety and health, please wear lab coats and disposable gloves for operation.
        2. 
	
      2. For research use only!
        3. 

      


       
      

      


      產(chǎn)品數(shù)據(jù)
      


      


      HB230207
      

         
       
       
       
       
       
       
       
      400-6111-883