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      Recombinant Human IL-23 Protein
       
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      產(chǎn)品說(shuō)明書(shū)
                  
      FAQ
                  
      COA
                  
      已發(fā)表文獻(xiàn)
                  
       
       
      


      IL-23 is a proinflammatory, heterodimeric protein composed of two subunits: a unique p19 subunit, and a p40 subunit that is shared with IL-12. IL-23 is secreted by activated dendritic cells and macrophages, and signals though a receptor comprised of IL-23R complexed with IL-12Rβ1. IL-23 has been shown to enhance proliferation of memory T cells.
      


       
      


      性能參數(shù)
      


      
	
		
      
			
			
      Synonyms
      
			      		
			
			
      Interleukin-23
      
			      		
		
      
		
      
			
			
      Source
      
			      		
			
			
      Sf 21 (baculovirus)
      
			      		
		
      
		
      
			
			
      Molecular Weight
      
			      		
			
			
      Apparent molecular mass of 65 kDa, 43-45 kDa and 20 kDa in SDS-PAGE under reducing conditions.
      
			      		
		
      
		
      
			
			
      AA Sequence
      
			      		
			
			
      Human IL-23 p40（Ile23-Ser328）&Human IL-23 p19 (Ala21-Pro189, Accession # AAG37232)
      
			      		
		
      
		
      
			
			
      Biological Activity
      
			      		
			
			
      Measured by its ability to induce IL-17 secretion by mouse splenocytes. The ED50 for this effect is 0.05-0.3 ng/mL..
      
			      		
		
      
		
      
			
			
      Purity
      
			      		
			
			
      > 95% by SDS-PAGE.
      
			      		
		
      
		
      
			
			
      Endotoxin
      
			      		
			
			
      <1.0 EU per 1μg of the protein by the LAL method.
      
			      		
		
      
		
      
			
			
      Formulation
      
			      		
			
			
      Lyophilized from 0.2 μm filtered concentrated sterile solution in 20 mM MES, pH 6.0, 500 mM NaCl and 1 mM EDTA.
      
			      		
		
      
		
      
			
			
      Reconstitution
      
			      		
			
			
      We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20°C. Further dilutions should be made in appropriate buffered solutions.
      
			      		
		
      
	      

      


       
      


      儲(chǔ)存條件
      


      The product should be stored at -25~-15℃ for 1 year from date of receipt.
      


      1 month, 2 ~8 °C under sterile conditions after reconstitution.
      


      3 months, -25~-15℃ under sterile conditions after reconstitution.
      


      Recommend to aliquot the protein into smaller quantities when first used and avoid repeated freeze-thaw cycles.
      


       
      


      注意事項(xiàng)
      


      1.Please operate with lab coats and disposable gloves,for your safety.
      


      2.This product is for research use only. 
      


      Ver. CN20230508
      

         
       
       
       
       
       
       
       
      400-6111-883