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      Phospho-JNK (Thr183/Tyr185) Rabbit pAb
       
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      產(chǎn)品說(shuō)明書(shū)
                  
      FAQ
                  
      COA
                  
      已發(fā)表文獻(xiàn)
                  
       
       
      


      The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported.
      


       
      


      產(chǎn)品性質(zhì)
      


      
	
		
      
			
			
      別名
      
			      		
			
			
      AI849689; c Jun N terminal kinase 1; C-JUN kinase 1; c-Jun N-terminal kinase 1; EC 2.7.11.24; JAK 1A; JAK1A; JNK 1; JNK 46; JNK; JNK-46; JNK1A2; JNK21B1/2; MAP kinase 8; MAPK 8; MAPK8; Mitogen activated protein kinase 8; Mitogen-activated protein kinase 8; MK08_HUMAN; p54 gamma; PRKM 8; PRKM8; Protein kinase JNK1; Protein kinase; mitogen-activated; 8; SAPK 1; SAPK gamma; SAPK1; Stress activated protein kinase JNK1; Stress-activated protein kinase 1; Stress-activated protein kinase JNK1; Tyrosine protein kinase JAK1 .
      
			      		
		
      
		
      
			
			
      SwissProt ID
      
			      		
			
			
      P45983
      
			      		
		
      
		
      
			
			
      基因ID
      
			      		
			
			
      5599
      
			      		
		
      
		
      
			
			
      免疫原
      
			      		
			
			
      The antiserum was produced against synthesized peptide derived from human JNK1/2/3 around the phosphorylation site of Thr183 and Tyr185. AA range:151-200.
      
			      		
		
      
		
      
			
			
      緩沖液
      
			      		
			
			
      Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
      
			      		
		
      
		
      
			
			
      分子量
      
			      		
			
			
      Calculated MW: 48 kDa; Observed MW：46, 54 kDa
      
			      		
		
      
		
      
			
			
      克隆類型
      
			      		
			
			
      Polyclonal Antibody
      
			      		
		
      
		
      
			
			
      宿主
      
			      		
			
			
      Rabbit
      
			      		
		
      
		
      
			
			
      物種反應(yīng)
      
			      		
			
			
      Human, Mouse, Rat, Chicken
      
			      		
		
      
		
      
			
			
      推薦應(yīng)用
      
			      		
			
			
      WB, IHC, ICC/IF, ELISA
      
			      		
		
      
		
      
			
			
      純化方式
      
			      		
			
			
      Affinity Purified
      
			      		
		
      
	      

      


       
      


      應(yīng)用
      


      稀釋比 WB：1/500-1/1000；IHC: 1/50-1/100; IF: 1/50-1/200; ELISA: 1/10000
      


       
      


      儲(chǔ)存條件
      


      -25~-15℃保存
      


       
      


      注意事項(xiàng)
      


      1. 避免反復(fù)凍融。
      


      2. 本產(chǎn)品僅作科研用途。
      


      3. 為了您的安全和健康，請(qǐng)穿實(shí)驗(yàn)服并佩戴一次性手套操作。
      


       
      


      產(chǎn)品數(shù)據(jù)
      


      


      Ver.CN20230907
      


       
      

         
       
       
       
       
       
       
       
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