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      Recombinant Human Fc gamma RIIIA/CD16a (F176)(His-Avi Tag)
       
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      產(chǎn)品說明書
                  
      FAQ
                  
      COA
                  
      已發(fā)表文獻(xiàn)
                  
       
      

      Fc gamma RIIIa is a low/intermediate affinity receptor for polyvalent immune-complexed IgG. It is involved in phagocytosis, secretion of enzymes and inflammatory mediators, antibody-dependent cytotoxicity and clearance of immune complexes. In humans, it is a 50-70 kDa type I transmembrane activating receptor expressed by NK cells, T cells, monocytes, and macrophages. Fc gamma RIIIb is highly related, sharing 97% amino acid (aa) identity within the extracellular domain (ECD), but is a GPI-linked receptor expressed on human neutrophils and eosinophils. The ECD of Fc gamma RIIIa shares 63%, 61%, 65%, 59% and 58% aa identity with mouse Fc gamma RIV, rat Fc gamma RIIIa, feline CD16, bovine CD16 and porcine Fc gamma RIIIb paralogs, respectively. The Fc gamma RIIIa cDNA encodes 254 aa including a 16 aa signal sequence, 191 aa ECD with two C2-type Ig-like domains and five potential N-glycosylation sites, a 22 aa transmembrane (TM) sequence and a 25 aa cytoplasmic domain. 
      


       
      


      產(chǎn)品性質(zhì)
      


      
	
		
      
			
			
      別名（Synonyms）
      
			      		
			
			
      Fc gamma RIIIA; FCGR3; FCGR3A; FCGRIII; FcgRIIIA; FcR-10; CD16A; FCG3; IGFR3; FcRIIIa; FcRIII; CD16; IMD20
      
			      		
		
      
		
      
			
			
      Uniprot No.
      
			      		
			
			
       P08637-1
      
			      		
		
      
		
      
			
			
      表達(dá)區(qū)間及表達(dá)系統(tǒng)（Source）
      
			      		
			
			
      Recombinant Human Fc gamma RIIIA/CD16a (F176) Protein is expressed from HEK293 Cells with His tag and Avi tag at the C-terminal.. It contains Gly17-Gln208(F176).
      
			      		
		
      
		
      
			
			
      分子量(Molecular Weight)
      
			      		
			
			
      The protein has a predicted MW of 24.7 kDa. Due to glycosylation, the protein migrates to 48-58 kDa based on Tris-Bis PAGE result.
      
			      		
		
      
		
      
			
			
      外觀(Physical Appearance）
      
			      		
			
			
      Sterile Filtered White lyophilized (freeze-dried) powder.
      
			      		
		
      
		
      
			
			
      純度（Purity）
      
			      		
			
			
      > 95% as determined by SDS-PAGE and HPLC
      
			      		
		
      
		
      
			
			
      活性（Activity）
      
			      		
			
			
      ELISA Data：Immobilized Human Fc gamma RIIIA (F176) , His Tag at 2μg/ml (100μl/well) 
      

			
      on the plate. Dose response curve for Anti-Fc gamma RIIIA Antibody, hFc Tag with the EC50 
      

			
      of 9.5ng/ml determined by ELISA.
      

			
      SPR Data: Human Fc gamma RIIIA (F176) , His Tag captured on CM5 Chip via anti-His 
      

			
      antibody can bind Rituximab, hFc Tag with an affinity constant of 0.92μM as determined
      

			
       in SPR assay.
      
			      		
		
      
		
      
			
			
      內(nèi)毒素（Endotoxin）
      
			      		
			
			
      < 1.0 EU per 1μg of the protein by the LAL method.
      
			      		
		
      
		
      
			
			
      制劑（Formulation）
      
			      		
			
			
      Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 5% trehalose is added as protectant before lyophilization.
      
			      		
		
      
		
      
			
			
      復(fù)溶（Reconstitution）
      
			      		
			
			
      Centrifuge tubes before opening. Reconstituting to a concentration more than 100 μg/mL is recommended (usually we use 1 mg/mL solution for lyophilization). Dissolve the lyophilized protein in distilled water.
      
			      		
		
      
	      

      


       
      

      


      

      運(yùn)輸與保存方法
      


      冰袋運(yùn)輸。-20℃至-80℃保存，一年有效期。
      


      復(fù)溶后，-20 至 -80°C，在未開封狀態(tài)下保存 3-6 個(gè)月。復(fù)溶后，2-8°C 保存 2-7 天。
      


      建議第一次使用時(shí)分裝凍存，避免反復(fù)凍融。
      


       
      


      注意事項(xiàng)
      


      1.避免反復(fù)凍融。
      


      2.為了您的安全和健康，請穿實(shí)驗(yàn)服并戴一次性手套操作。
      


      3.本產(chǎn)品僅作科研用途！
      


       
      


      產(chǎn)品數(shù)據(jù)
      


      


      

      


      HB220624
      

         
       
       
       
       
       
       
       
      400-6111-883