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      Recombinant SARS-COV-2 Spike S1 Protein,His Tag
       
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      產(chǎn)品說明書
                  
      FAQ
                  
      COA
                  
      已發(fā)表文獻(xiàn)
                  
       
      

       
      


      SARS-CoV-2 Spike Protein (S Protein) is a glycoprotein that mediates membrane fusion and viral entry. The S Protein of the SARS-CoV-2 virus binds Angiotensin-Converting Enzyme 2 (ACE-2), but with much higher affinity and faster binding kinetics . Polyclonal antibodies to the RBD of the SARS-CoV-2 S1 subunit have been shown to inhibit interaction with the ACE-2 receptor, confirming RBD as an attractive target for vaccinations or antiviral therapy . There is also promising work showing that the RBD may be used to detect presence of neutralizing antibodies present in a patient's bloodstream, consistent with developed immunity after exposure to the SARS-CoV-2 virus. Lastly, it has been demonstrated the S Protein can invade host cells through the CD147/EMMPRIN receptor and mediate membrane fusion. 
      


       
      


      產(chǎn)品性質(zhì)
      


      
	
		
      
			
			
      別名
      
			      		
			
			
      S1 protein; Spike protein S1; Spike,S1 protein; S glycoprotein Subunit1
      
			      		
		
      
		
      
			
			
      Accession
      
			      		
			
			
      QHO60594.1
      
			      		
		
      
		
      
			
			
      表達(dá)區(qū)間及表達(dá)系統(tǒng)
      
			      		
			
			
      Recombinant SARS-COV-2 Spike S1 Protein is expressed from HEK293 Cells with His tag at the C-terminal. It contains Gln14-Arg683.
      
			      		
		
      
		
      
			
			
      分子量
      
			      		
			
			
      Approximately 76.1 kDa. Due to glycosylation, the protein migrates to 115-140 kDa based on Tris-Bis PAGE result.
      
			      		
		
      
		
      
			
			
      純度
      
			      		
			
			
      > 95% as determined by SDS-PAGE and HPLC.
      
			      		
		
      
		
      
			
			
      活性
      
			      		
			
			
      ELISA Data：Immobilized SARS-COV-2 Spike S1, His Tag at 1μg/ml (100μl/Well) on the plate. Dose response curve for Human ACE2, hFc Tag with the EC50 of 19.4ng/ml determined by ELISA.
      
			      		
		
      
		
      
			
			
      內(nèi)毒素
      
			      		
			
			
      < 1.0 EU per 1μg of the protein by the LAL method.
      
			      		
		
      
		
      
			
			
      制劑
      
			      		
			
			
      Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 5% trehalose is added as protectant before lyophilization.
      
			      		
		
      
		
      
			
			
      復(fù)溶
      
			      		
			
			
      Centrifuge tubes before opening. Reconstituting to a concentration more than 100 μg/mL is recommended (usually we use 1 mg/mL solution for lyophilization). Dissolve the lyophilized protein in distilled water.
      
			      		
		
      
	      

      


       
      


      運(yùn)輸與保存方法
      


      冰袋運(yùn)輸。-20℃保存，一年有效期。
      


      復(fù)溶后，-20 °C，在未開封狀態(tài)下保存 3-6 個(gè)月。復(fù)溶后，2-8°C 保存 2-7 天。
      


      建議第一次使用時(shí)分裝凍存，避免反復(fù)凍融。
      


       
      

      


      注意事項(xiàng)
      


        
	
      1. 避免反復(fù)凍融。
        2. 
	
      2. 為了您的安全和健康，請(qǐng)穿實(shí)驗(yàn)服并戴一次性手套操作。
        3. 
	
      3. 本產(chǎn)品僅作科研用途！
        4. 

      


       
      


      產(chǎn)品數(shù)據(jù)
      


      


      


      HB221025
      

         
       
       
       
       
       
       
       
      400-6111-883